Protein dynamics: whispering within.
نویسنده
چکیده
Dynamic communication between atoms within folded proteins is potentially important for function, but its measurement has been a challenge. Now, a combined NMR and modelling study provides insights on the presence and strengths of such correlations.
منابع مشابه
Effects of T208E activating mutation on MARK2 protein structure and dynamics: Modeling and simulation
Microtubule Affinity-Regulating Kinase 2 (MARK2) protein has a substantial role in regulation of vital cellular processes like induction of polarity, regulation of cell junctions, cytoskeleton structure and cell differentiation. The abnormal function of this protein has been associated with a number of pathological conditions like Alzheimer disease, autism, several carcinomas and development of...
متن کاملUltra-Sensitive Optical Biosensor Based on Whispering Gallery Modes: The Effect of Buffer Solutions Refractive Index on Their Sensitivity and Performance
Background: Whispering gallery modes (WGM) biosensors are ultrasensitive systems that can measure amount of adsorbed layer onto the micro-cavity surface. They have many applications including protein, peptide growth, DNA and bacteria detection, molecular properties measurements and specific interaction and drug table recognitions due to their high sensitivity, compact size and label free sensin...
متن کاملChaotic Light: a Theory of Asymmetric Resonant Cavities Jens U. Nöckel and A. Douglas Stone
Spherical and cylindrical dielectric cavities support high Q whispering gallery modes due to total internal reflection of the trapped light. When such a cavity is deformed smoothly the ray dynamics of these modes becomes chaotic in a manner determined by the KAM theory of classical hamiltonian dynamics. The universal properties of the ray dynamics predicted by KAM theory allow a general underst...
متن کاملDynamics of alaninaminotransferase activity in subcellular fractions of different areas of brain cortex and hypothalamus in postnatal ontogenesis under protein-free feeding regime and after its withdrawal
Total and specific activities of alaninaminotransferase (Al-AT) were determined in general tissues, mitochondrial and cytosol fractions of visual, orbital, motor, limbic areas of brain cortex and hypothalamus of three-month old and one-year old rats under 10-20 days and 30 days protein deprivation and under recovery of normal food regime during the same terms. It was found out that Al-AT activi...
متن کاملDynamics of alaninaminotransferase activity in subcellular fractions of different areas of brain cortex and hypothalamus in postnatal ontogenesis under protein-free feeding regime and after its withdrawal
Total and specific activities of alaninaminotransferase (Al-AT) were determined in general tissues, mitochondrial and cytosol fractions of visual, orbital, motor, limbic areas of brain cortex and hypothalamus of three-month old and one-year old rats under 10-20 days and 30 days protein deprivation and under recovery of normal food regime during the same terms. It was found out that Al-AT activi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Nature chemistry
دوره 3 9 شماره
صفحات -
تاریخ انتشار 2011